ERβ scientific visions translate to clinical uses

被引:31
作者
Gustafsson, J. -A. [1 ]
机构
[1] Karolinska Inst, Novum, Dept Biosci & Nutr, SE-14186 Stockholm, Sweden
关键词
autoimmune diseases; endometriosis; depression; hypertension; ER beta agonist;
D O I
10.1080/14689360600734328
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Estrogen receptor beta (ER beta) was discovered in 1995 and reported on in 1996. During the 10 years following this event, our understanding of estrogen signaling has changed remarkably. We now know that estradiol, the major endogenous activator of ER, is nonselective for the two receptors, and that ER alpha and ER beta are, in many contexts, antagonistic against one another, an example of a yin/yang relationship, perhaps nature's way to accomplish subtle regulatory changes of estrogen signaling as a response to ever-shifting physiological requirements. Needless to say, this knowledge is of paramount significance pharmaceutically, and several ER beta-selective agonists, intended for use against a multitude of diseases, have already been synthesized and patented by drug companies. Clearly, the next 5-10 years will be extremely exciting in view of results from clinical trials testing the clinical utility of ER beta targeted drugs.
引用
收藏
页码:156 / 160
页数:5
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