Human breast epithelial stem cells and their regulation

被引：34

作者：

Kalirai, H ^{[1
]}

Clarke, RB ^{[1
]}

机构：

[1] Univ Manchester, Christie Hosp NHS Trust, Breast Biol Grp, Div Canc Studies, Manchester M20 4BX, Lancs, England

来源：

JOURNAL OF PATHOLOGY | 2006年 / 208卷 / 01期

关键词：

breast; stem cell; cancer; self-renewal; signalling pathway;

D O I：

10.1002/path.1881

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review summarizes the current evidence for the existence of human breast stem cells and the pathways involved in their regulation, and discusses how the disruption of these pathways may result in the generation of a population of cells with the capacity for unlimited self-renewal. Relevant data from mouse model systems are also discussed where appropriate. By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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收藏

页码：7 / 16

页数：10

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