Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3

被引：23

作者：

Blagbrough, IS

Moya, E

Walford, SP

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, Claverton Down

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 04期

关键词：

D O I：

10.1016/0040-4039(95)02238-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical, total synthesis of polyamine amide spider toxin NSTX-3; a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreamine and regioselective acylation of L-asparaginyl-cadaverine.

引用

页码：551 / 554

页数：4

共 23 条

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