Biomimetic Synthesis of Collagen/Nano-Hydroxyapitate Scaffold for Tissue Engineering

被引：31

作者：

Liu, Chao-zong ^{[1
]}

机构：

[1] Robert Gordon Univ, Sch Engn, Adv Mat & Biomat Res Ctr, Sch Hill, Aberdeen AB10 1FR, Scotland

来源：

JOURNAL OF BIONIC ENGINEERING | 2008年 / 5卷 / Suppl 1期

关键词：

collagen; hydroxyapatite; gradient scaffold; microstructure; chemical composition;

D O I：

10.1016/S1672-6529(08)60064-5

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This paper reports a precipitation method for the fabrication of compositionally graded biomimetic collagen/nano-hydroxyapatite (HA) composite scaffold. The method is centrifugation based and produce the precipitation of nano-HA crystallites in situ (calcium ions (Ca2+) react phosphate ions (PO43-) and precipitate a non-stoichiometric hydroxyapatite). It was observed that prism needle-like nano-HA crystallites (about 2.5 nm x 3 nm x 25 nm) precipitated on collagen fibrils in the interior of collagen matrix. Chemical and microstructure analysis revealed a gradient of the Ca to P ratio across the width of the scaffold, lead to the formation of a HA-rich side and a HA-deplete side of scaffold. The HA-rich side featured low porosity and agglomerates of the nano-HA crystallites; while HA-depleted side featured higher porosity and nano-HA crystallites integrated with collagen fibrils to form a porous network structure.

引用

页码：1 / 8

页数：8

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