Oxygen metabolism in oral cancer: HIF and GLUTs (Review)

被引：48

作者：

Alves Pereira, Karuza Maria ^{[1
]}

Chaves, Filipe Nobre ^{[2
]}

Angelim Viana, Thales Salles ^{[2
]}

Rodrigues Carvalho, Francisco Samuel ^{[3
,4
]}

Gurgel Costa, Fabio Wildson ^{[5
,6
]}

Negreiros Nunes Alves, Ana Paula ^{[2
]}

Sousa, Fabricio Bitu ^{[2
]}

机构：

[1] Univ Fed Ceara, Sch Dent, Div Oral Pathol, BR-62010560 Sobral, Brazil

[2] Univ Fed Ceara, Sch Dent, Dept Clin Dent, Div Stomatol, BR-60430160 Fortaleza, Ceara, Brazil

[3] Univ Fed Ceara, Div Stomatol, BR-62010560 Sobral, Brazil

[4] Univ Fed Ceara, Div Oral & Maxillofacial Surg, BR-62010560 Sobral, Brazil

[5] Univ Fed Ceara, Div Radiol, Sch Dent, BR-62010560 Sobral, Brazil

[6] Univ Fed Ceara, Div Stomatol, Sch Dent, BR-62010560 Sobral, Brazil

来源：

ONCOLOGY LETTERS | 2013年 / 6卷 / 02期

关键词：

cancer; carcinoma; squamous cells; glucose transport proteins; facilitative hypoxia-inducible factor-1 alpha; oral cancer; SQUAMOUS-CELL CARCINOMA; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; GLUCOSE TRANSPORTERS GLUT-1; NECK-CANCER; POOR-PROGNOSIS; EXPRESSION; HEAD; TUMOR; OVEREXPRESSION; RADIOTHERAPY;

D O I：

10.3892/ol.2013.1371

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Oral cancer is a significant cause of morbidity and mortality, and has a poor prognosis. This has encouraged additional studies into factors that may affect the development of this disease. The biological behavior of malignant neoplasms is complex. Studies have investigated the energy metabolism of tumor cells, in an endeavor to elucidate the tumor biology. The identification of molecular signatures and mechanisms, in order to understand tumor progression, may facilitate the identification of novel predictive and prognostic markers. Pathways that influence tumor progression, such as those involving hypoxia-inducible factor (HIF) and glucose transporter (GLUT) proteins, have been the targets of recent studies.

引用

页码：311 / 316

页数：6

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