Recent advances in head and neck cancer

被引:724
作者
Haddad, Robert I. [1 ,2 ,3 ]
Shin, Dong M. [4 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
[4] Emory Univ, Dept Hematol Oncol, Winship Canc Inst, Atlanta, GA 30322 USA
关键词
D O I
10.1056/NEJMra0707975
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There are more than half a million incident cases of squamous-cell carcinoma of the head and neck worldwide each year, primarily affecting the oropharynx, oral cavity, hypopharynx, and larynx. This review considers the biologic features of these tumors, including the role of human papillomavirus as a risk factor for cancer of the oropharynx. New therapies are considered, along with management approaches. Copyright © 2008 Massachusetts Medical Society.
引用
收藏
页码:1143 / 1154
页数:12
相关论文
共 95 条
  • [1] Intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer
    Adelstein, DJ
    Li, Y
    Adams, GL
    Wagner, H
    Kish, JA
    Ensley, JF
    Schuller, DE
    Forastiere, AA
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) : 92 - 98
  • [2] Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized intergroup study 0099
    Al-Sarraf, M
    LeBlanc, M
    Giri, PGS
    Fu, KK
    Cooper, J
    Vuong, T
    Forastiere, AA
    Adams, G
    Sakr, WA
    Schuller, DE
    Ensley, JF
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (04) : 1310 - 1317
  • [3] A phase III trial to compare standard versus accelerated fractionation in combination with concurrent cisplatin for head and neck carcinomas (RTOG (1129): Report of compliance and toxicity
    Ang, K.
    Pajak, T.
    Rosenthall, D. I.
    Nguyen, F.
    Lu, C.
    Kim, H.
    Axelrod, R.
    List, M.
    Silverman, C.
    Weber, R. S.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (03): : S12 - S13
  • [4] Ang KK, 2002, CANCER RES, V62, P7350
  • [5] [Anonymous], N ENGL J MED
  • [6] Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells
    Bandyopadhyay, D
    Mandal, M
    Adam, L
    Mendelsohn, J
    Kumar, R
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (03) : 1568 - 1573
  • [7] Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    Bergers, G
    Song, S
    Meyer-Morse, N
    Bergsland, E
    Hanahan, D
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (09) : 1287 - 1295
  • [8] Defining risk levels in locally advanced head and neck cancers:: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (#9501)
    Bernier, J
    Cooper, JS
    Pajak, TF
    van Glabbeke, M
    Bourhis, J
    Forastiere, A
    Ozsahin, EM
    Jacobs, JR
    Jassem, J
    Ang, KK
    Lefèbvre, JL
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2005, 27 (10): : 843 - 850
  • [9] Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer
    Bernier, J
    Domenge, C
    Ozsahin, M
    Matuszewska, K
    Lefèbvre, JL
    Greiner, RH
    Giralt, J
    Maingon, P
    Rolland, F
    Bolla, M
    Cognetti, F
    Bourhis, J
    Kirkpatrick, A
    van Glabbeke, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (19) : 1945 - 1952
  • [10] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    Bonner, JA
    Harari, PM
    Giralt, J
    Azarnia, N
    Shin, DM
    Cohen, RB
    Jones, CU
    Sur, R
    Raben, D
    Jassem, J
    Ove, R
    Kies, MS
    Baselga, J
    Youssoufian, H
    Amellal, N
    Rowinsky, EK
    Ang, KK
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) : 567 - 578