Collectins - Players of the innate immune system

被引:169
作者
van de Wetering, JK [1 ]
van Golde, LMG [1 ]
Batenburg, JJ [1 ]
机构
[1] Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, Gras Sch Anim Hlth, NL-3508 TD Utrecht, Netherlands
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 2004年 / 271卷 / 07期
关键词
collectin; C-type lectin; mannan-binding lectin (MBL); surfactant protein A (SP-A); surfactant protein D (SP-D); innate immunity; host defense; surface epitopes; pulmonary surfactant; infectious disease;
D O I
10.1111/j.1432-1033.2004.04040.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Collectins are a family of collagenous calcium-dependent defense lectins in animals. Their polypeptide chains consist of four regions: a cysteine-rich N-terminal domain, a collagen-like region, an alpha-helical coiled-coil neck domain and a C-terminal lectin or carbohydrate-recognition domain. These polypeptide chains form trimers that may assemble into larger oligomers. The best studied family members are the mannan-binding lectin, which is secreted into the blood by the liver, and the surfactant proteins A and D, which are secreted into the pulmonary alveolar and airway lining fluid. The collectins represent an important group of pattern recognition molecules, which bind to oligosaccharide structures and/or lipid moities on the surface of microorganisms. They bind preferentially to monosaccharide units of the mannose type, which present two vicinal hydroxyl groups in an equatorial position. High-affinity interactions between collectins and microorganisms depend, on the one hand, on the high density of the carbohydrate ligands on the microbial surface, and on the other, on the degree of oligomerization of the collectin. Apart from binding to microorganisms, the collectins can interact with receptors on host cells. Binding of collectins to microorganisms may facilitate microbial clearance through aggregation, complement activation, opsonization and activation of phagocytosis, and inhibition of microbial growth. In addition, the collectins can modulate inflammatory and allergic responses, affect apoptotic cell clearance and modulate the adaptive immune system.
引用
收藏
页码:1229 / 1249
页数:21
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