The role of apelin in cardiovascular function and heart failure

被引：145

作者：

Chandrasekaran, Badrinathan ^{[1
]}

Dar, Owais ^{[1
]}

McDonagh, Theresa ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, London SW3 6NP, England

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2008年 / 10卷 / 08期

关键词：

apelin; APJ; heart failure;

D O I：

10.1016/j.ejheart.2008.06.002

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the angiotensin II-angiotensin II type I receptor pathway. It is a peripheral vasodilator, powerful inotrope and may affect central fluid homeostasis. Animal and human Studies Suggest that it may play a role in the pathogenesis of heart failure by modulating the harmful effects of angiotensin II. Apelin is reduced in patients with heart failure and up regulated following favourable left ventricular remodelling. It is widely distributed in a number of tissues, mainly restricted to vascular endothelium. This comprehensive review of the literature highlights the important Studies that have led to the discovery of apelin and its role in cardiovascular function and heart failure. (c) 2008 European Society of Cardiology. Published by Elsevier B.V All rights reserved.

引用

页码：725 / 732

页数：8

共 76 条

[1]

The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo [J].

Ashley, EA ;

Powers, J ;

Chen, M ;

Kundu, R ;

Finsterbach, T ;

Caffarelli, A ;

Deng, A ;

Eichhorn, J ;

Mahajan, R ;

Agrawal, R ;

Greve, J ;

Robbins, R ;

Patterson, AJ ;

Bernstein, D ;

Quertermous, T .

CARDIOVASCULAR RESEARCH, 2005, 65 (01) :73-82

[2]

Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression [J].

Atluri, Pavan ;

Morine, Kevin J. ;

Liao, George P. ;

Panlilio, Corinna M. ;

Berry, Mark F. ;

Hsu, Vivian M. ;

Hiesinger, William ;

Cohen, Jeffrey E. ;

Woo, Y. Joseph .

CELLULAR & MOLECULAR BIOLOGY LETTERS, 2007, 12 (01) :127-138

[3]

Apelin has in vivo inotropic effects on normal and failing hearts [J].

Berry, MF ;

Pirolli, TJ ;

Jayasankar, V ;

Burdick, J ;

Morine, KJ ;

Gardner, TJ ;

Woo, YJ .

CIRCULATION, 2004, 110 (11) :II187-II193

[4]

Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry [J].

Cayabyab, M ;

Hinuma, S ;

Farzan, M ;

Choe, H ;

Fukusumi, S ;

Kitada, C ;

Nishizawa, N ;

Hosoya, M ;

Nishimura, O ;

Messele, T ;

Pollakis, G ;

Goudsmit, J ;

Fujino, M ;

Sodroski, J .

JOURNAL OF VIROLOGY, 2000, 74 (24) :11972-11976

[5]

Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep [J].

Charles, Christopher J. ;

Rademaker, Miriam T. ;

Richards, A. Mark .

JOURNAL OF ENDOCRINOLOGY, 2006, 189 (03) :701-710

[6]

Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction [J].

Chen, MM ;

Ashley, EA ;

Deng, DXF ;

Tsalenko, A ;

Deng, A ;

Tabibiazar, R ;

Ben-Dor, A ;

Fenster, B ;

Yang, E ;

King, JY ;

Fowler, M ;

Robbins, R ;

Johnson, FL ;

Bruhn, L ;

McDonagh, T ;

Dargie, H ;

Yakhini, Z ;

Tsao, PS ;

Quertermous, T .

CIRCULATION, 2003, 108 (12) :1432-1439

[7]

Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats [J].

Cheng, X ;

Cheng, XS ;

Pang, CCY .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 470 (03) :171-175

[8]

Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure [J].

Chong, KS ;

Gardner, RS ;

Morton, JJ ;

Ashley, EA ;

McDonagh, TA .

EUROPEAN JOURNAL OF HEART FAILURE, 2006, 8 (04) :355-360

[9]

Evidence for decreased circulating apelin beyond heart involvement in uremic cardiomyopathy [J].

Codognotto, Marta ;

Piccoli, Antonio ;

Zaninotto, Martina ;

Mion, Monica ;

Vertolli, Ugo ;

Tona, Francesco ;

Boffa, Giovanni M. .

AMERICAN JOURNAL OF NEPHROLOGY, 2007, 27 (01) :1-6

[10]

Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo [J].

Cox, Christopher M. ;

D'Agostino, Susan L. ;

Miller, Melanie K. ;

Heimark, Ronald L. ;

Krieg, Paul A. .

DEVELOPMENTAL BIOLOGY, 2006, 296 (01) :177-189

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