Epstein-Barr virus and rheumatoid arthritis: is there a link?

被引：67

作者：

Costenbader, KH ^{[1
]}

Karlson, EW ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Div Rheumatol Immunol & All, Boston, MA 02115 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2006年 / 8卷 / 01期

关键词：

D O I：

10.1186/ar1893

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic, destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental factors trigger development in the genetically predisposed. Epstein-Barr virus, a nearly ubiquitous virus in the human population, has generated great interest as a potential trigger. This virus stimulates polyclonal lymphocyte expansion and persists within B lymphocytes for the host's life, inhibited from reactivating by the immune response. In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed.

引用

页数：7

共 131 条

[1] Mechanisms of disease: Molecular mimicry and autoimmunity. [J].

Albert, LJ ;

Inman, RD .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (27) :2068-2074

[2] LYMPHOCYTES TRANSFORMED BY EPSTEIN-BARR VIRUS - INDUCTION OF NUCLEAR ANTIGEN REACTIVE WITH ANTIBODY IN RHEUMATOID-ARTHRITIS [J].

ALSPAUGH, MA ;

JENSEN, FC ;

RABIN, H ;

TAN, EM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 147 (04) :1018-1027

[3]

ALSPAUGH MA, 1976, ARTHRITIS RHEUM-US, V19, P711, DOI 10.1002/1529-0131(197607/08)19:4<711::AID-ART1780190409>3.0.CO

[4]

2-I

[5] ELEVATED LEVELS OF ANTIBODIES TO EPSTEIN-BARR VIRUS-ANTIGENS IN SERA AND SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATOID-ARTHRITIS [J].

ALSPAUGH, MA ;

HENLE, G ;

LENNETTE, ET ;

HENLE, W .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (04) :1134-1140

[6] Epstein-Barr virus antibodies and risk of multiple sclerosis -: A prospective study [J].

Ascherio, A ;

Munger, KL ;

Lennette, ET ;

Spiegelman, D ;

Hernán, MA ;

Olek, MJ ;

Hankinson, SE ;

Hunter, DJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (24) :3083-3088

[7]

BABOONIAN C, 1989, RHEUMATOL INT, V9, P161

[8]

Baeten D, 2001, ARTHRITIS RHEUM, V44, P2255, DOI 10.1002/1529-0131(200110)44:10<2255::AID-ART388>3.0.CO

[9]

2-#

[10] Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis - Accurate quantification using real-time polymerase chain reaction [J].

Balandraud, N ;

Meynard, JB ;

Auger, I ;

Sovran, H ;

Mugnier, B ;

Reviron, D ;

Roudier, J ;

Roudier, C .

ARTHRITIS AND RHEUMATISM, 2003, 48 (05) :1223-1228

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