Epstein-Barr virus and rheumatoid arthritis: is there a link?

被引：67

作者：

Costenbader, KH ^{[1
]}

Karlson, EW ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Div Rheumatol Immunol & All, Boston, MA 02115 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2006年 / 8卷 / 01期

关键词：

D O I：

10.1186/ar1893

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic, destructive, debilitating arthritis. Its etiology is unknown; it is presumed that environmental factors trigger development in the genetically predisposed. Epstein-Barr virus, a nearly ubiquitous virus in the human population, has generated great interest as a potential trigger. This virus stimulates polyclonal lymphocyte expansion and persists within B lymphocytes for the host's life, inhibited from reactivating by the immune response. In latent and replicating forms, it has immunomodulating actions that could play a role in the development of this autoimmune disease. The evidence linking Epstein-Barr virus and rheumatoid arthritis is reviewed.

引用

页数：7

共 131 条

[91] Serological and clinical findings in patients with serological evidence of reactivated Epstein-Barr virus infection [J].