Interferon regulatory factors: Growth control and histone gene regulation - It's not just interferon anymore

被引：44

作者：

Vaughan, PS

vanWijnen, AJ

Stein, JL

Stein, GS

机构：

[1] Department of Cell Biology, Univ. of Massachusetts Cancer Center

[2] Department of Cell Biology, Cancer Center, Univ. of Massachusetts Med. Center, Worcester, MA 01655

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1997年 / 75卷 / 05期

关键词：

interferon; histone; transcription; cell cycle; proliferation;

D O I：

10.1007/s001090050120

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the beta-interferon gene and many interferon-stimulated genes. Two well-studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-beta gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1. IRF-1 and IRF-2 have more recently been linked to growth control by displaying turner suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.

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收藏

页码：348 / 359

页数：12

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