Identification of a point mutation in the para-type sodium channel gene from a pyrethroid-resistant cattle tick

被引:126
作者
He, HQ
Chen, AC
Davey, RB
Ivie, GW
George, JE
机构
[1] ARS, USDA, Food Anim Protect Res Lab, College Stn, TX 77845 USA
[2] ARS, Cattle Fever Tick Res Lab, USDA, Mission, TX 78573 USA
[3] ARS, Knipling Bushland US Livestock Insects Res La, USDA, Kerrville, TX 78028 USA
关键词
Boophilus microplus; insecticide; acaricide; resistance;
D O I
10.1006/bbrc.1999.1076
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To investigate the molecular mechanism of resistance to pyrethroids in the southern cattle tick, Boophilus microplus, we have obtained and sequenced a partial para-homologous sodium channel cDNA from susceptible and pyrethroid-resistant tick strains. A point mutation that results in an amino acid change from Phe to lie was identified in the highly conserved domain IIIS6 of the homologous sodium channel from ticks that are highly resistant to pyrethroid acaricides, This mutation is at a location different from those reported in the same gene in pyrethroid-resistant insects, (C) 1999 Academic Press.
引用
收藏
页码:558 / 561
页数:4
相关论文
共 22 条
[21]   KNOCKDOWN RESISTANCE (KDR) TO DDT AND PYRETHROID INSECTICIDES MAPS TO A SODIUM-CHANNEL GENE LOCUS IN THE HOUSEFLY (MUSCA-DOMESTICA) [J].
WILLIAMSON, MS ;
DENHOLM, I ;
BELL, CA ;
DEVONSHIRE, AL .
MOLECULAR AND GENERAL GENETICS, 1993, 240 (01) :17-22
[22]   Identification of mutations in the housefly para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides [J].
Williamson, MS ;
MartinezTorres, D ;
Hick, CA ;
Devonshire, AL .
MOLECULAR AND GENERAL GENETICS, 1996, 252 (1-2) :51-60