Just Say No to ATOH: How HIC1 Methylation Might Predispose Medulloblastoma to Lineage Addiction

被引：21

作者：

Briggs, Kimberly J. ^{[2
]}

Eberhart, Charles G. ^{[2
,3
]}

Watkins, D. Neil ^{[1
,2
]}

机构：

[1] Monash Med Ctr, Monash Inst Med Res, Clayton, Vic 3168, Australia

[2] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 21期

关键词：

D O I：

10.1158/0008-5472.CAN-08-1904

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypermethylated in cancer-1 (HICI) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HICI is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HICI function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1. [Cancer Res 2008;68(21):8654-6]

引用

页码：8654 / 8656

页数：3

共 34 条

[1] Math1 is essential for genesis of cerebellar granule neurons [J].

BenArie, N ;

Bellen, HJ ;

Armstrong, DL ;

McCall, AE ;

Gordadze, PR ;

Guo, QX ;

Matzuk, MM ;

Zoghbi, HY .

NATURE, 1997, 390 (6656) :169-172

[2] Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma [J].

Briggs, Kimberly J. ;

Corcoran-Schwartz, Ian M. ;

Zhang, Wei ;

Harcke, Thomas ;

Devereux, Wendy L. ;

Baylin, Stephen B. ;

Eberhart, Charles G. ;

Watkins, D. Neil .

GENES & DEVELOPMENT, 2008, 22 (06) :770-785

[3] Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses [J].

Chen, WY ;

Wang, DH ;

Yen, RWC ;

Luo, JY ;

Gu, W ;

Baylin, SB .

CELL, 2005, 123 (03) :437-448

[4]

COGEN PH, 1992, AM J HUM GENET, V50, P584

[5]

Dahmane N, 1999, DEVELOPMENT, V126, P3089

[6] RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma [J].

Di Marcotullio, L ;

Ferretti, E ;

De Smaele, E ;

Argenti, B ;

Mincione, C ;

Zazzeroni, F ;

Gallo, R ;

Masuelli, L ;

Napolitano, M ;

Maroder, M ;

Modesti, A ;

Giangaspero, F ;

Screpanti, I ;

Alesse, E ;

Gulino, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) :10833-10838

[7]

Eads CA, 2001, CANCER RES, V61, P3410

[8] Medulloblastoma in mice lacking p53 and PARP - A roads lead to Gli [J].

Eberhart, CG .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (01) :7-10

[9] Medulloblastoma stem cells [J].

Fan, Xing ;

Eberhart, Charles G. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (17) :2821-2827

[10] Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer [J].

Fujii, H ;

Biel, MA ;

Zhou, WB ;

Weitzman, SA ;

Baylin, SB ;

Gabrielson, E .

ONCOGENE, 1998, 16 (16) :2159-2164

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