Just Say No to ATOH: How HIC1 Methylation Might Predispose Medulloblastoma to Lineage Addiction

被引：21

作者：

Briggs, Kimberly J. ^{[2
]}

Eberhart, Charles G. ^{[2
,3
]}

Watkins, D. Neil ^{[1
,2
]}

机构：

[1] Monash Med Ctr, Monash Inst Med Res, Clayton, Vic 3168, Australia

[2] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 21期

关键词：

D O I：

10.1158/0008-5472.CAN-08-1904

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hypermethylated in cancer-1 (HICI) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HICI is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HICI function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1. [Cancer Res 2008;68(21):8654-6]

引用

页码：8654 / 8656

页数：3

共 34 条

[11] Lineage Addiction in human cancer: Lessons from integrated genomics [J].

Garraway, L. A. ;

Weir, B. A. ;

Zhao, X. ;

Widlund, H. ;

Beroukhim, R. ;

Berger, A. ;

Rimm, D. ;

Rubin, M. A. ;

Fisher, D. E. ;

Meyerson, M. L. ;

Sellers, W. R. .

MOLECULAR APPROACHES TO CONTROLLING CANCER, 2005, 70 :25-34

[12] Lineage dependency and lineage-survival oncogenes in human cancer [J].

Garraway, Levi A. ;

Sellers, William R. .

NATURE REVIEWS CANCER, 2006, 6 (08) :593-602

[13] Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway [J].

Gazit, R ;

Krizhanovsky, V ;

Ben-Arie, N .

DEVELOPMENT, 2004, 131 (04) :903-913

[14] Clinical and molecular stratification of disease risk in medulloblastoma [J].

Gilbertson, R ;

Wickramasinghe, C ;

Hernan, R ;

Balaji, V ;

Hunt, D ;

Jones-Wallace, D ;

Crolla, J ;

Perry, R ;

Lunec, J ;

Pearson, A ;

Ellison, D .

BRITISH JOURNAL OF CANCER, 2001, 85 (05) :705-712

[15] Altered neural cell fates and medulloblastoma in mouse patched mutants [J].

Goodrich, LV ;

Milenkovic, L ;

Higgins, KM ;

Scott, MP .

SCIENCE, 1997, 277 (5329) :1109-1113

[16]

Issa JPJ, 1997, LEUKEMIA, V11, pS7

[17] Analysis of cerebellar development in math1 null embryos and chimeras [J].

Jensen, P ;

Smeyne, R ;

Goldowitz, D .

JOURNAL OF NEUROSCIENCE, 2004, 24 (09) :2202-2211

[18] DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis [J].

Kanai, Y ;

Hui, AM ;

Sun, L ;

Ushijima, S ;

Sakamoto, M ;

Tsuda, H ;

Hirohashi, S .

HEPATOLOGY, 1999, 29 (03) :703-709

[19] DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis [J].

Kanai, Y ;

Ushijima, S ;

Ochiai, A ;

Eguchi, K ;

Hui, AM ;

Hirohashi, S .

CANCER LETTERS, 1998, 122 (1-2) :135-141

[20] Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors [J].

Kenney, AM ;

Cole, MD ;

Rowitch, DH .

DEVELOPMENT, 2003, 130 (01) :15-28

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