The art of microRNA: Various strategies leading to gene silencing via an ancient pathway

被引：65

作者：

Tang, Guiliang ^{[1
,2
]}

Tang, Xiaoqing ^{[3
]}

Mendu, Venugopal ^{[1
,2
]}

Tang, Xiaohu ^{[1
,2
]}

Jia, Xiaoyun ^{[1
,2
]}

Chen, Qi-Jun ^{[1
,2
]}

He, Liheng ^{[1
,2
]}

机构：

[1] Univ Kentucky, Dept Plant & Soil Sci, Gene Suppress Lab, Lexington, KY 40546 USA

[2] Univ Kentucky, KTRDC, Lexington, KY 40546 USA

[3] Univ Kentucky, Coll Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2008年 / 1779卷 / 11期

基金：

美国国家科学基金会;

关键词：

miRNA; RISC; Target cleavage; Translational repression;

D O I：

10.1016/j.bbagrm.2008.06.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

MicroRNAs (miRNAs), an endogenous type of small RNAs of similar to 22 nucleotides (nt), have long resided in the cells of plants and animals including humans, constituting an ancient pathway of gene regulation in eukaryotes. They have a simple structure in their mature form but carry enormous information that may regulate up to 90% of the human transcriptome. Furthermore, the multi-facets of a miRNA are tightly associated with diverse cellular proteins that make it broadly connected to various physiological and pathological processes. This review aims to examine miRNAs briefly from their biogenesis to their general functions with an emphasis on working mechanisms in regulation of their target mRNAs. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：655 / 662

页数：8

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