The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication

被引：248

作者：

Yant, Levi J.

Friedrich, Thomas C.

Johnson, Randall C.

May, Gemma E.

Maness, Nicholas J.

Enz, Alissa M.

Lifson, Jeffrey D.

O'Connor, David H.

Carrington, Mary

Watkins, David I.

机构：

[1] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA

[2] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA

[3] NCI, Basic Res Program, Lab Gen Divers, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21702 USA

[4] Sci Appl Int Corp Fredrick, AIDS Vaccine Program, Basic Res Program, Frederick, MD 21072 USA

来源：

JOURNAL OF VIROLOGY | 2006年 / 80卷 / 10期

关键词：

D O I：

10.1128/JVI.80.10.5074-5077.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B*17 was associated with a 26-fold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17 was also enriched 1,000-fold in a group of animals that controlled viral replication. Even after accounting for this group, Mamu-B*17 was associated with an eightfold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control.

引用

页码：5074 / 5077

页数：4

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