Cyclic nucleotide-gated ion channels in sensory transduction

被引：80

作者：

Pifferi, Simone ^{[1
]}

Boccaccio, Anna ^{[1
]}

Menini, Anna ^{[1
]}

机构：

[1] SISSA, Sch Adv Int Studies, Sector Neurobiol, I-34014 Trieste, Italy

来源：

FEBS LETTERS | 2006年 / 580卷 / 12期

关键词：

transduction; sensory; adaptation; olfaction; cAMP; channelopathy;

D O I：

10.1016/j.febslet.2006.03.086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclic nucleotide-gated (CNG) channels, directly activated by the binding of cyclic nucleotides, were first discovered in retinal rods, cones and olfactory sensory neurons. In the visual and olfactory systems, CNG channels mediate sensory transduction by conducting cationic currents carried primarily by sodium and calcium ions. In olfactory transduction, calcium in combination with calmodulin exerts a negative feedback on CNG channels that is the main molecular mechanism responsible for fast adaptation in olfactory sensory neurons. Six mammalian CNG channel genes are known and some human visual disorders are caused by mutations in retinal rod or cone CNG genes. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2853 / 2859

页数：7

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