Enantiometric cross-inhibition in the synthesis of oligonucleotides on a nonchiral template

被引：50

作者：

Schmidt, JG ^{[1
]}

Nielsen, PE ^{[1
]}

Orgel, LE ^{[1
]}

机构：

[1] SALK INST BIOL STUDIES,SAN DIEGO,CA 92186

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 06期

关键词：

D O I：

10.1021/ja963563c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptide nucleic acids (PNA) are used as a model for a precursor of RNA in experiments that examine enantiomeric cross-inhibition. Experiments were conducted to facilitate comparison with prior research. Results indicate that enantiomeric cross-inhibition is as problematic in the polymerization of nucleotides on PNA as in RNA and DNA templates.

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收藏

页码：1494 / 1495

页数：2

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