The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations

被引：265

作者：

Page, Mahalia E. ^{[1
,2
]}

Lombard, Patrick ^{[1
,3
]}

Ng, Felicia ^{[1
,3
]}

Goettgens, Berthold ^{[1
,3
]}

Jensen, Kim B. ^{[1
,2
,4
]}

机构：

[1] Wellcome Trust Med Res Council Cambridge Stem Cel, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Oncol, Cambridge CB2 0QQ, England

[3] Cambridge Inst Med Res, Dept Haematol, Cambridge CB2 0XY, England

[4] Univ Copenhagen, Biotech Res & Innovat Ctr, DK-2200 Copenhagen N, Denmark

来源：

CELL STEM CELL | 2013年 / 13卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

HAIR FOLLICLE; PROGENITOR CELLS; SEBACEOUS GLAND; MOUSE EPIDERMIS; WOUND REPAIR; SKIN; LRIG1; HOMEOSTASIS; KERATINOCYTES; MAINTENANCE;

D O I：

10.1016/j.stem.2013.07.010

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

The complex anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which they functionally overlap during homeostasis, wound healing, and tumor initiation remains poorly defined. Here, we demonstrate that Lrig1(+ve) cells are highly proliferative epidermal stem cells. Longterm clonal analysis reveals that Lrig1(+ve) cells maintain the upper pilosebaceous unit, containing the infundibulum and sebaceous gland as independent compartments, but contribute to neither the hair follicle nor the interfollicular epidermis, which are maintained by distinct stem cell populations. In contrast, upon wounding, stem cell progeny from multiple compartments acquire lineage plasticity and make permanent contributions to regenerating tissue. We further show that oncogene activation in Lrig1(+ve) cells drives hyperplasia but requires auxiliary stimuli for tumor formation. In summary, our data demonstrate that epidermal stem cells are lineage restricted during homeostasis and suggest that compartmentalization may constitute a conserved mechanism underlying epithelial tissue maintenance.

引用

页码：471 / 482

页数：12

共 51 条

[1]

Tracking cells in their native habitat: lineage tracing in epithelial neoplasia [J].