Epidermal homeostasis: a balancing act of stem cells in the skin

被引：895

作者：

Blanpain, Cedric ^{[2
]}

Fuchs, Elaine ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

[2] Univ Libre Bruxelles, Inst Rech Interdisciplinaire Biol Humaine & Mol, B-1070 Brussels, Belgium

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 03期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

HAIR FOLLICLE MORPHOGENESIS; LABEL-RETAINING CELLS; BETA-CATENIN; TRANSIENT ACTIVATION; TRANSGENIC MOUSE; MULTIPLE ROLES; GROWTH-PHASE; DIFFERENTIATION; BULGE; PROLIFERATION;

D O I：

10.1038/nrm2636

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The skin epidermis and its array of appendages undergo ongoing renewal by a process called homeostasis. Stem cells in the epidermis have a crucial role in maintaining tissue homeostasis by providing new cells to replace those that are constantly lost during tissue turnover or following injury. Different resident skin stem cell pools contribute to the maintenance and repair of the various epidermal tissues of the skin, including interfollicular epidermis, hair follicles and sebaceous glands. Interestingly, the basic mechanisms and signalling pathways that orchestrate epithelial morphogenesis in the skin are reused during adult life to regulate skin homeostasis.

引用

页码：207 / U67

页数：12

共 104 条

[21] CHANGES IN KERATIN GENE-EXPRESSION DURING TERMINAL DIFFERENTIATION OF THE KERATINOCYTE
FUCHS, E
GREEN, H
[J]. CELL, 1980, 19 (04) : 1033 - 1042
[22] PERMANENT COVERAGE OF LARGE BURN WOUNDS WITH AUTOLOGOUS CULTURED HUMAN EPITHELIUM
GALLICO, GG
OCONNOR, NE
COMPTON, CC
KEHINDE, O
GREEN, H
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (07) : 448 - 451
[23] De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin
Gat, U
DasGupta, R
Degenstein, L
Fuchs, E
[J]. CELL, 1998, 95 (05) : 605 - 614
[24] Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin
Ghazizadeh, S
Taichman, LB
[J]. EMBO JOURNAL, 2001, 20 (06) : 1215 - 1222
[25] Mechanisms of asymmetric cell division:: flies and worms pave the way
Goenczy, Pierre
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (05) : 355 - 366
[26] THE SECRET LIFE OF THE HAIR FOLLICLE
HARDY, MH
[J]. TRENDS IN GENETICS, 1992, 8 (02) : 55 - 61
[27] NFATc1 balances quiescence and proliferation of skin stem cells
Horsley, Valerie
Aliprantis, Antonios O.
Polak, Lisa
Glimcher, Laurie H.
Fuchs, Elaine
[J]. CELL, 2008, 132 (02) : 299 - 310
[28] Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
Horsley, Valerie
O'Carroll, Donal
Tooze, Reuben
Ohinata, Yasuhide
Saitou, Mitinori
Obukhanych, Tetyana
Nussenzweig, Michel
Tarakhovsky, Alexander
Fuchs, Elaine
[J]. CELL, 2006, 126 (03) : 597 - 609
[29] HOSEONG YS, 2008, NAT GENET, V40, P1130
[30] β-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
Huelsken, J
Vogel, R
Erdmann, B
Cotsarelis, G
Birchmeier, W
[J]. CELL, 2001, 105 (04) : 533 - 545

← 1 2 3 4 5 6 7 8 9 10 →