Neurological perspectives on voltage-gated sodium channels

被引：266

作者：

Eijkelkamp, Niels ^{[1
]}

Linley, John E. ^{[1
]}

Baker, Mark D. ^{[2
]}

Minett, Michael S. ^{[1
]}

Cregg, Roman ^{[1
]}

Werdehausen, Robert ^{[1
,3
]}

Rugiero, Francois ^{[1
]}

Wood, John N. ^{[1
]}

机构：

[1] UCL, Wolfson Inst Biomed Res, Mol Nocicept Grp, London WC1E 6BT, England

[2] Neurosci Inst Cell & Mol Sci Barts & London Sch M, London E1 2AT, England

[3] Univ Dusseldorf, Fac Med, Dept Anaesthesiol, D-40225 Dusseldorf, Germany

来源：

BRAIN | 2012年 / 135卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

ion channel; genetics; pain; epilepsy; SCN1A; EXTREME PAIN DISORDER; SEVERE MYOCLONIC EPILEPSY; SPINAL SENSORY NEURONS; PERSISTENT NA+ CURRENT; FEBRILE SEIZURES-PLUS; GATING CHARGE MOVEMENT; ROOT GANGLION NEURONS; OF-FUNCTION MUTATIONS; TETRODOTOXIN-RESISTANT; NEUROPATHIC PAIN;

D O I：

10.1093/brain/aws225

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.

引用

页码：2585 / 2612

页数：28

共 339 条

[121] Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties [J].

Hakim, Parvez ;

Gurung, Iman S. ;

Pedersen, Thomas H. ;

Thresher, Rosemary ;

Brice, Nicola ;

Lawrence, Jason ;

Grace, Andrew A. ;

Huang, Christopher L. -H. .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2008, 98 (2-3) :251-266

[122] On the relationship between block of the cardiac Na+ channel and drug-induced prolongation of the QRS complex [J].

Harmer, A. R. ;

Valentin, J-P ;

Pollard, C. E. .

BRITISH JOURNAL OF PHARMACOLOGY, 2011, 164 (02) :260-273

[123] Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital [J].

Hasegawa, H .

CURRENT MEDICAL RESEARCH AND OPINION, 2004, 20 (05) :577-580

[124]

Heblich Fay, 2008, Channels (Austin), V2, P4

[125] Intrinsic and extrinsic determinants of ion channel localization in neurons [J].

Hedstrom, Kristian L. ;

Rasband, Matthew N. .

JOURNAL OF NEUROCHEMISTRY, 2006, 98 (05) :1345-1352

[126] Pharmacological disruption of calcium channel trafficking by the α2δ ligand gabapentin [J].

Hendrich, Jan ;

Van Minh, Alexandra Tran ;

Heblich, Fay ;

Nieto-Rostro, Manuela ;

Watschinger, Katrin ;

Striessnig, Joerg ;

Wratten, Jack ;

Davies, Anthony ;

Dolphin, Annette C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) :3628-3633

[127] Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects [J].

Herfst, LJ ;

Potet, F ;

Bezzina, CR ;

Groenewegen, WA ;

Le Marec, H ;

Hoorntje, TM ;

Demolombe, S ;

Baro, I ;

Escande, D ;

Jongsma, HJ ;

Wilde, AAM ;

Rook, MB .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2003, 35 (05) :549-557

[128] Overexpression of NaV1.6 channels is associated with the invasion capacity of human cervical cancer [J].

Hernandez-Plata, Everardo ;

Ortiz, Cindy S. ;

Marquina-Castillo, Brenda ;

Medina-Martinez, Ingrid ;

Alfaro, Ana ;

Berumen, Jaime ;

Rivera, Manuel ;

Gomora, Juan C. .

INTERNATIONAL JOURNAL OF CANCER, 2012, 130 (09) :2013-2023

[129] Sodium-channel defects in benign familial neonatal-infantile seizures [J].

Heron, SE ;

Crossland, KM ;

Andermann, E ;

Phillips, HA ;

Hall, AJ ;

Bleasel, A ;

Shevell, M ;

Mercho, S ;

Seni, MH ;

Guiot, MC ;

Mulley, JC ;

Berkovic, SF ;

Scheffer, IE .

LANCET, 2002, 360 (9336) :851-852

[130] The use-dependent sodium channel blocker mexiletine is neuroprotective against global ischemic injury [J].

Hewitt, KE ;

Stys, PK ;

Lesiuk, HJ .

BRAIN RESEARCH, 2001, 898 (02) :281-287

← 8 9 10 11 12 13 14 15 16 17 →