Stem cell therapy for cerebral ischemia: from basic science to clinical applications

被引：100

作者：

Abe, Koji ^{[1
]}

Yamashita, Toru ^{[1
]}

Takizawa, Shunya ^{[2
]}

Kuroda, Satoshi ^{[3
]}

Kinouchi, Hiroyuki ^{[4
]}

Kawahara, Nobutaka ^{[5
]}

机构：

[1] Okayama Univ, Sch Med, Dept Neurol, Okayama 7008558, Japan

[2] Tokai Univ, Sch Med, Dept Neurol, Isehara, Kanagawa 25911, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Neurosurg, Sapporo, Hokkaido, Japan

[4] Yamanashi Univ, Dept Neurosurg, Sch Med, Kofu, Yamanashi 400, Japan

[5] Yokohama City Univ, Grad Sch Med, Dept Neurosurg, Yokohama, Kanagawa 232, Japan

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2012年 / 32卷 / 07期

关键词：

cerebral ischemia; neuroregeneration; neurorepair; stem cell therapy; MARROW STROMAL CELLS; COLONY-STIMULATING FACTOR; SPINAL-CORD-INJURY; HEPATOCYTE GROWTH-FACTOR; GELATIN-SILOXANE HYBRID; BONE-MARROW; G-CSF; IN-VIVO; SUBVENTRICULAR ZONE; FOLLOW-UP;

D O I：

10.1038/jcbfm.2011.187

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent stem cell technology provides a strong therapeutic potential not only for acute ischemic stroke but also for chronic progressive neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis with neuroregenerative neural cell replenishment and replacement. In addition to resident neural stem cell activation in the brain by neurotrophic factors, bone marrow stem cells (BMSCs) can be mobilized by granulocyte-colony stimulating factor for homing into the brain for both neurorepair and neuroregeneration in acute stroke and neurodegenerative diseases in both basic science and clinical settings. Exogenous stem cell transplantation is also emerging into a clinical scene from bench side experiments. Early clinical trials of intravenous transplantation of autologous BMSCs are showing safe and effective results in stroke patients. Further basic sciences of stem cell therapy on a neurovascular unit and neuroregeneration, and further clinical advancements on scaffold technology for supporting stem cells and stem cell tracking technology such as magnetic resonance imaging, single photon emission tomography or optical imaging with near-infrared could allow stem cell therapy to be applied in daily clinical applications in the near future. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 1317-1331; doi: 10.1038/jcbfm.2011.187; published online 18 January 2012

引用

页码：1317 / 1331

页数：15

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