Functional neuroimages of cortical myoclonus altered by levetiracetam in a patient with sialidosis

被引：5

作者：

Chen, Kuan-Fei ^{[1
,6
,7
]}

Lai, Szu-Chia ^{[4
]}

Wu, Yu-Chin ^{[2
,3
,8
]}

Lu, Chin-Song ^{[4
]}

Lu, Ming-Kuei ^{[1
,5
]}

Tsai, Chon-Haw ^{[1
,5
,6
]}

机构：

[1] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[3] China Med Univ Hosp, PET Ctr, Taichung, Taiwan

[4] Chang Gung Mem Hosp, Dept Neurol, Tao Yuan, Taiwan

[5] China Med Univ, Grad Inst Neural & Cognit Sci, Taichung, Taiwan

[6] China Med Univ, Coll Med, Taichung, Taiwan

[7] China Med Univ, Beigang Hosp, Dept Neurol, Yunlin, Taiwan

[8] Natl Taiwan Univ Hosp, Dept Med Image, Hsin Chu Branch, Hsinchu, Taiwan

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2013年 / 20卷 / 02期

关键词：

Levetiracetam; Myoclonus; Sialidosis; EXPRESSION;

D O I：

10.1016/j.jocn.2012.02.024

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Levetiracetam can suppress sialidosis-related myoclonus but its effects on cerebral metabolism warrant elucidation. In this report, fluorodeoxyglucose-positron emission tomography was conducted before and after levetiracetam in a sialidosis patient. By subtracting the drug "off" from "on" signals, regions of enhanced metabolism were shown to be allocated mostly in the bilateral fronto-temporal regions whereas regions of reduced metabolism were distributed mainly in the occipital areas. Imaging changes suggest that the effects of levetiracetam may be different in different brain regions. The drug may also elicit fronto-temporal inhibitory impulses to suppress the vigorous myoclonus in sialidosis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：318 / 319

页数：2

共 9 条

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DIFFERENTIAL EXPRESSION OF SYNAPTIC VESICLE PROTEIN-2 (SV2) ISOFORMS [J].