Functional neuroimages of cortical myoclonus altered by levetiracetam in a patient with sialidosis

被引:5
作者
Chen, Kuan-Fei [1 ,6 ,7 ]
Lai, Szu-Chia [4 ]
Wu, Yu-Chin [2 ,3 ,8 ]
Lu, Chin-Song [4 ]
Lu, Ming-Kuei [1 ,5 ]
Tsai, Chon-Haw [1 ,5 ,6 ]
机构
[1] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan
[2] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan
[3] China Med Univ Hosp, PET Ctr, Taichung, Taiwan
[4] Chang Gung Mem Hosp, Dept Neurol, Tao Yuan, Taiwan
[5] China Med Univ, Grad Inst Neural & Cognit Sci, Taichung, Taiwan
[6] China Med Univ, Coll Med, Taichung, Taiwan
[7] China Med Univ, Beigang Hosp, Dept Neurol, Yunlin, Taiwan
[8] Natl Taiwan Univ Hosp, Dept Med Image, Hsin Chu Branch, Hsinchu, Taiwan
关键词
Levetiracetam; Myoclonus; Sialidosis; EXPRESSION;
D O I
10.1016/j.jocn.2012.02.024
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Levetiracetam can suppress sialidosis-related myoclonus but its effects on cerebral metabolism warrant elucidation. In this report, fluorodeoxyglucose-positron emission tomography was conducted before and after levetiracetam in a sialidosis patient. By subtracting the drug "off" from "on" signals, regions of enhanced metabolism were shown to be allocated mostly in the bilateral fronto-temporal regions whereas regions of reduced metabolism were distributed mainly in the occipital areas. Imaging changes suggest that the effects of levetiracetam may be different in different brain regions. The drug may also elicit fronto-temporal inhibitory impulses to suppress the vigorous myoclonus in sialidosis. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:318 / 319
页数:2
相关论文
共 9 条
[1]
DIFFERENTIAL EXPRESSION OF SYNAPTIC VESICLE PROTEIN-2 (SV2) ISOFORMS [J].
BAJJALIEH, SM ;
FRANTZ, GD ;
WEIMANN, JM ;
MCCONNELL, SK ;
SCHELLER, RH .
JOURNAL OF NEUROSCIENCE, 1994, 14 (09) :5223-5235
[2]
Alterations of intracerebral γ-aminobutyric acid (GABA) levels by titration with levetiracetam in patients with focal epilepsies [J].
Doelken, Marc T. ;
Hammen, Thilo ;
Bogner, Wolfgang ;
Mennecke, Angelika ;
Stadlbauer, Andreas ;
Boettcher, Uwe ;
Doerfler, Arnd ;
Stefan, Hermann .
EPILEPSIA, 2010, 51 (08) :1477-1482
[3]
Medio-Frontal and Anterior Temporal abnormalities in children with attention deficit hyperactivity disorder (ADHD) during an acoustic antisaccade task as revealed by electro-cortical source reconstruction [J].
Goepel, Johanna ;
Kissler, Johanna ;
Rockstroh, Brigitte ;
Paul-Jordanov, Isabella .
BMC PSYCHIATRY, 2011, 11
[4]
Region-specific changes in gene expression in rat brain after chronic treatment with levetiracetam or phenytoin [J].
Hassel, Bjornar ;
Tauboll, Erik ;
Shaw, Renee ;
Gjerstad, Leif ;
Dingledine, Ray .
EPILEPSIA, 2010, 51 (09) :1714-1720
[5]
Post-hypoxic cortical myoclonus mimicking spinal myoclonus - electrophysiological and functional MRI manifestations [J].
Huang, H. -C. ;
Chen, J. -C. ;
Lu, M. -K. ;
Chen, J. -M. ;
Tsai, C. -H. .
EUROPEAN JOURNAL OF NEUROLOGY, 2011, 18 (01) :E4-E5
[6]
A longitudinal study of Taiwanese Sialidosis type 1: an insight into the concept of cherry-red spot myoclonus syndrome [J].
Lai, S. -C. ;
Chen, R. -S. ;
Chou, Y. -H. Wu ;
Chang, H. -C. ;
Kao, L. -Y. ;
Huang, Y. -Z. ;
Weng, Y. -H. ;
Chen, J. -K. ;
Hwu, W. -L. ;
Lu, C. -S. .
EUROPEAN JOURNAL OF NEUROLOGY, 2009, 16 (08) :912-919
[7]
Levetiracetam inhibits glutamate transmission through presynaptic P/Q-type calcium channels on the granule cells of the dentate gyrus [J].
Lee, Chun-Yao ;
Chen, Chih-Chuan ;
Liou, Horng-Huei .
BRITISH JOURNAL OF PHARMACOLOGY, 2009, 158 (07) :1753-1762
[8]
Nishiyama Y, 1997, Rinsho Shinkeigaku, V37, P982
[9]
Epileptic negative myoclonus: SPECT, PET, and video/EEG studies and the dramatic effects of levetiracetam [J].
Yu, Hsiang-Yu ;
Kwan, Shang-Yeong ;
Lirng, Jiing-Feng ;
Liao, Kwong-Kum ;
Chu, Yum-Kung ;
Liao, Shu-Quinn .
EPILEPSY & BEHAVIOR, 2009, 14 (04) :687-690