Epileptic negative myoclonus: SPECT, PET, and video/EEG studies and the dramatic effects of levetiracetam

被引：10

作者：

Yu, Hsiang-Yu ^{[1
,2
]}

Kwan, Shang-Yeong ^{[1
,2
]}

Lirng, Jiing-Feng ^{[2
,3
]}

Liao, Kwong-Kum ^{[1
,2
]}

Chu, Yum-Kung ^{[4
]}

Liao, Shu-Quinn ^{[4
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Neurol, Taipei, Taiwan

[2] Natl Yang Ming Univ, Taipei 112, Taiwan

[3] Taipei Vet Gen Hosp, Dept Radiol, Taipei, Taiwan

[4] Taipei Vet Gen Hosp, Dept Nucl Med, Taipei, Taiwan

来源：

EPILEPSY & BEHAVIOR | 2009年 / 14卷 / 04期

关键词：

Epileptic negative myoclonus; 2-Deoxy-2-[F-18]fluoro-D-glucose positron emission tomography; Levetiracetam; Technetium-99m-ethyl cysteinate dimer single-photon emission computed tomography; SEIZURES;

D O I：

10.1016/j.yebeh.2009.01.025

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

An 18-year-old woman presented with epileptic negative myoclonus (ENM) as her major seizure pattern for 4 years. Her seizures were characterized by intermittent postural lapse of the right limbs for a period of hours to 2 days. Ictal electroencephalography (EEG)-electromyography showed a silent period that was time-locked to generalized spike-wave discharges. Video/EEG monitoring demonstrated marked improvement of ENM after oral administration of levetiracetam. Cranial magnetic resonance imaging was normal, but 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography during frequent ENM showed hypometabolism in the left frontoparietal cortex. Technetium-99m-ethyl cysteinate dimer single-photon emission computed tomography revealed hyperperfusion over the left parietal cortex and putamen. Here, we document the short-term effects of levetiracetam in this subject with nearly isolated ENM and the neuroimaging results during ENM. Long-term follow-up is in progress to evaluate the clinical evolution and long-term effects of levetiracetam on ENM. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：687 / 690

页数：4

共 15 条

[1]

Epileptic negative myoclonus: An EEG-single-photon emission CT study indicating involvement of premotor cortex [J].