Application of the Pictet-Spengler reaction in combinatorial chemistry.

被引：65

作者：

Mayer, JP

BankaitisDavis, D

Zhang, JW

Beaton, G

Bjergarde, K

Andersen, CM

Goodman, BA

Herrera, CJ

机构：

[1] Amgen Boulder Inc., Boulder, CO 80301

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 32期

关键词：

D O I：

10.1016/0040-4039(96)01219-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of polymer bound tryptophan with a variety of aldehydes and ketones under Pictet-Spengler like conditions was found to produce 1,2,3,4-tetrahydro-beta-carbolines in excellent yield. The straightforward, easily automated chemistry and the availability of numerous commercial aldehydes and ketones makes this approach ideal for combinatorial chemistry application. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：5633 / 5636

页数：4

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