Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases

被引：59

作者：

Baeriswyl, Vanessa ^{[1
]}

Rapley, Helen ^{[2
]}

Pollaro, Lisa ^{[1
]}

Stace, Catherine ^{[2
]}

Teufel, Dan ^{[2
]}

Walker, Edward ^{[2
]}

Chen, Shiyu ^{[1
]}

Winter, Greg ^{[3
]}

Tite, John ^{[2
]}

Heinis, Christian ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland

[2] Bicycle Therapeut Ltd, Cambridge CB22 3AT, England

[3] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

CHEMMEDCHEM | 2012年 / 7卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

bicyclic peptides; macrocycles; kallikreins; serine proteases; specificity; HEREDITARY ANGIOEDEMA; HEK-293; CELLS; EXPRESSION; COMPLEX;

D O I：

10.1002/cmdc.201200071

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1173 / 1176

页数：4

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