Factors associated with superior antibody responses to a single dose of Haemophilus influenzae type b tetanus toxoid conjugate vaccine administered to Chilean infants at 2 months of age

被引：22

作者：

Levine, OS

Granoff, DM

Lagos, R

Fritzell, B

Levine, MM

机构：

[1] UNIV MARYLAND, SCH MED, CTR VACCINE DEV, BALTIMORE, MD 21201 USA

[2] CHIRON BIOCINE, EMERYVILLE, CA 94608 USA

[3] CHILDRENS HOSP OAKLAND, RES INST, OAKLAND, CA 94609 USA

[4] CTR VACUNAS DESARROLLO, SERV SALUD METROPOLITANA NORTE, SANTIAGO, CHILE

[5] PASTEUR MERIEUX SERUMS & VACCINS, PARIS, FRANCE

来源：

VACCINE | 1997年 / 15卷 / 03期

关键词：

Haemophilus influenzae; conjugate vaccines; immunization;

D O I：

10.1016/S0264-410X(96)00161-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anticapsular antibody response of Chilean infants to a single dose of Haemophilus influenzae type b capsular polysaccharide-tetanus toroid conjugate vaccine is substantially higher than that observed among infants of similar age from the USA. Comparison of selected demographic and environmental factors indicates that low maternal education and a greater number of persons in the home are significantly associated with the superior responder phenotype. High anticapsular antibody responses were associated with high antibody responses to tetanus toroid the carrier protein in this conjugate, but not to diphtheria toxoid. These data suggest that environmental factors may enhance the magnitude of the primary antibody response to PRP-T vaccine. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：325 / 328

页数：4

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