In vitro BACE-1 Inhibitory Phenolic Components from the Seeds of Psoralea corylifolia

被引：88

作者：

Choi, Yeon Hee ^{[1
]}

Yon, Gyu Hwan ^{[1
]}

Hong, Kyung Sik ^{[1
]}

Yoo, Dae Seok ^{[1
]}

Choi, Chun Whan ^{[1
]}

Park, Woo-Kyu ^{[1
]}

Kong, Jae Yang ^{[1
]}

Kim, Young Sup ^{[1
]}

Ryu, Shi Yong ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Taejon 305343, South Korea

来源：

PLANTA MEDICA | 2008年 / 74卷 / 11期

关键词：

Psoralea corylifolia L; Fabaceae; BACE-1; isoflavones; neocorylin;

D O I：

10.1055/s-2008-1081301

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new isoflavone, neocorylin (1) was isolated from the seeds extract of Psoralea corylifolia L. (Fabaceae), together with eight known constituents (2-9), i.e., bakuchiol (2), psoralen (3), bavachromene (4), isobavachromene (5), bavachalcone (6), isobavachalcone (7), 7,8-dihydro-8-(4-hydrophenyl)-2,2-dimethyl-2H,6H-[1,2-b:5,4-b']dipyran-6-one (8), and bavachinin (9). The structure of the new isoflavone 1 was elucidated as 7-hydroxy-3-[2-methyl-2-(4-methylpenten-3-yl)-2H-chromen-6-yl]-4H- chromen-4-one by spectroscopic analyses. Neocorylin (1) as well as related compounds 2, 4-6, 8 and 9 exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.

引用

页码：1405 / 1408

页数：4

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