Positive selection of thymocytes: the long and winding road

被引：63

作者：

Anderson, G ^{[1
]}

Hare, KJ ^{[1
]}

Jenkinson, EJ ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Dept Anat, MRC,Ctr Immune Regulat,Div Infect & Immun, Birmingham B15 2TT, W Midlands, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0167-5699(99)01524-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Positive selection is a crucial stage in T-cell development because it is here that CD4(+)CD8(+) cells bearing T-cell receptors that interact with self-major histocompatibility complex molecules are rescued from cell death, resulting in the generation of mature T cells. Here, Graham Anderson and colleagues review recent studies indicating that positive selection is a multistage process involving interactions with thymic epithelium.

引用

页码：463 / 468

页数：6

共 60 条

[51] T-CELL APOPTOSIS DETECTED IN-SITU DURING POSITIVE AND NEGATIVE SELECTION IN THE THYMUS
SURH, CD
SPRENT, J
[J]. NATURE, 1994, 372 (6501) : 100 - 103
[52] SMALL CD4(+)8(+)TCR(LOW) THYMOCYTES CONTAIN PRECURSORS OF MATURE T-CELLS
SWAT, W
VONBOEHMER, H
KISIELOW, P
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (04) : 1010 - 1012
[53] Tarazona R, 1998, J IMMUNOL, V160, P5397
[54] THYMIC MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND THE ALPHA-BETA-T-CELL RECEPTOR DETERMINE THE CD4/CD8 PHENOTYPE OF T-CELLS
TEH, HS
KISIELOW, P
SCOTT, B
KISHI, H
UEMATSU, Y
BLUTHMANN, H
VONBOEHMER, H
[J]. NATURE, 1988, 335 (6187) : 229 - 233
[55] Vanhecke D, 1997, J IMMUNOL, V158, P3730
[56] Quantitative impact of thymic clonal deletion on the T cell repertoire
vanMeerwijk, JPM
Marguerat, S
Lees, RK
Germain, RN
Fowlkes, BJ
MacDonald, HR
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (03) : 377 - 383
[57] Structure and function of the pre-T cell receptor
vonBoehmer, H
Fehling, HJ
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 433 - 452
[58] WILKINSON RW, 1995, J IMMUNOL, V155, P5234
[59] The agonist-antagonist balance in positive selection
Williams, O
Tanaka, Y
Tarazona, R
Kioussis, D
[J]. IMMUNOLOGY TODAY, 1997, 18 (03): : 121 - 126
[60] Yagi H, 1996, J IMMUNOL, V157, P3412

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