Microbial cell individuality and the underlying sources of heterogeneity

被引：388

作者：

Avery, Simon V. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Biol, Inst Genet, Nottingham NG7 2RD, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2006年 / 4卷 / 08期

关键词：

D O I：

10.1038/nrmicro1460

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Single cells in genetically homogeneous microbial cultures exhibit marked phenotypic individuality, a biological phenomenon that is considered to bolster the fitness of populations. Major phenotypes that are characterized by heterogeneity span the breadth of microbiology, in fields ranging from pathogenicity to ecology. The cell cycle, cell ageing and epigenetic regulation are proven drivers of heterogeneity in several of the best-known phenotypic examples. However, the full contribution of factors such as stochastic gene expression is yet to be realized.

引用

页码：577 / 587

页数：11

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