Ring opening of optically active cis-disubstituted aziridino alcohols: An enantiodivergent synthesis of functionalized amino alcohol derivatives

被引：25

作者：

Fuji, K ^{[1
]}

Kawabata, T ^{[1
]}

Kiryu, Y ^{[1
]}

Sugiura, Y ^{[1
]}

机构：

[1] KYOTO UNIV,INST CHEM RES,UJI,KYOTO 611,JAPAN

来源：

HETEROCYCLES | 1996年 / 42卷 / 02期

关键词：

D O I：

10.3987/COM-95-S76

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ring-opening reactions of optically active cis-disubstituted aziridino alcohols have been investigated. Regio- and stereo-selective ring opening took place with internal and external nucleophiles. Unusual amino acids derivatives (14) and (15), the key synthetic intermediates for bestatin and related peptides, have been prepared.

引用

页码：701 / 722

页数：22

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