Notch Signaling and T-Helper Cells in EAE/MS

被引：15

作者：

Bassil, Ribal ^{[1
]}

Orent, William ^{[1
]}

Elyaman, Wassim ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2013年

关键词：

GATA3; EXPRESSION; DENDRITIC CELLS; UP-REGULATION; LIGAND; DIFFERENTIATION; INDUCTION; ENCEPHALOMYELITIS; ACTIVATION; DELTA1; SUPPRESSION;

D O I：

10.1155/2013/570731

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in embryogenesis, tissue homeostasis, angiogenesis, and immunoregulation. Multiple sclerosis ( MS) is an incurable yet treatable autoimmune chronic inflammatory disease of the central nervous system. The aim of this review is to provide a brief description of the Notch signaling pathway, and summarize the current literature implicating Notch in the pathogenesis of MS.

引用

页数：7

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