Increased expression of monocyte chemoattractant protein-1 in atherectomy specimens from patients with restenosis after percutaneous transluminal coronary angioplasty

被引：26

作者：

Hokimoto, S

Oike, Y

Saito, T

Kitaoka, M

Oshima, S

Noda, K

Moriyama, Y

Ishibashi, F

Ogawa, H

机构：

[1] Kumamoto City Hosp, Div Cardiol, Kumamoto 8620965, Japan

[2] Kumamoto City Hosp, Div Pathol, Kumamoto 8620965, Japan

[3] Kumamoto Univ, Dept Cell Differentiat, Inst Embryol & Genet, Kumamoto, Japan

[4] Kumamoto Univ, Dept Cardiovasc Med, Sch Med, Kumamoto, Japan

来源：

CIRCULATION JOURNAL | 2002年 / 66卷 / 01期

关键词：

coronary artery disease; immunohistochemistry; restenosis;

D O I：

10.1253/circj.66.114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The plasma concentration of monocyte chemoattractant protein-1 (MCP-1) antigen is higher in patients with restenosis after coronary angioplasty than in those who do not restenose. In this study the MCP-1 expression of coronary atherectomy specimens was investigated by immunohistochemistry. Samples were obtained from 12 patients with restenosis and 15 with de novo lesions by directional coronary atherectomy. MCP-1 immunoreactivity was found in all patients in the restenosis group and in 8 of the de novo group. The frequency of macrophage expression was higher in the restenosis group than in de novo group. These results indicate that local expression of MCP-1 may be associated with the mechanisms of vascular remodeling after coronary angioplasty.

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收藏

页码：114 / 116

页数：3

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