Genetic regulation of aflatoxin biosynthesis: From gene to genome

被引：190

作者：

Georgianna, D. Ryan ^{[1
]}

Payne, Gary A. ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Plant Pathol, Raleigh, NC 27606 USA

来源：

FUNGAL GENETICS AND BIOLOGY | 2009年 / 46卷 / 02期

关键词：

Aflatoxin; Aspergillus; Genomics; Secondary metabolism; TRICARBOXYLIC-ACID CYCLE; ASPERGILLUS-FLAVUS; G-PROTEIN; SECONDARY METABOLISM; MYCOTOXIN PRODUCTION; TRANSCRIPTION FACTOR; MOLECULAR CHARACTERIZATION; SCLEROTIAL PRODUCTION; CHEMICAL DIVERSITY; TOXIN BIOSYNTHESIS;

D O I：

10.1016/j.fgb.2008.10.011

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aflatoxins are notorious toxic secondary metabolites known for their impacts on human and animal health, and their effects on the marketability of key grain and nut crops. Understanding aflatoxin biosynthesis is the focus of a large and diverse research community. Concerted efforts by this community have led not only to a well-characterized biosynthetic pathway, but also to the discovery of novel regulatory mechanisms. Common to secondary metabolism is the clustering of biosynthetic genes and their regulation by pathway specific as well as global regulators. Recent data show that arrangement of secondary metabolite genes in clusters may allow for an important global regulation of secondary metabolism based on physical location along the chromosome. Available genomic and proteomic tools are now allowing us to examine aflatoxin biosynthesis more broadly and to put its regulation in context with fungal development and fungal ecology. This review covers our current understanding of the biosynthesis and regulation of aflatoxin and highlights new and emerging information garnered from structural and functional genomics. The focus of this review will be on studies in Aspergillus flavus and Aspergillus parasiticus, the two agronomically important species that produce aflatoxin. Also covered will be the important contributions gained by studies on production of the aflatoxin precursor sterigmatocystin in Aspergillus nidulans. (C) 2009 Published by Elsevier Inc.

引用

页码：113 / 125

页数：13

共 160 条

[11] LaeA, a regulator of secondary metabolism in Aspergillus spp. [J].

Bok, JW ;

Keller, NP .

EUKARYOTIC CELL, 2004, 3 (02) :527-535

[12] SELECTIVE G-MUTATION TO T-MUTATION OF P53 GENE IN HEPATOCELLULAR-CARCINOMA FROM SOUTHERN AFRICA [J].

BRESSAC, B ;

KEW, M ;

WANDS, J ;

OZTURK, M .

NATURE, 1991, 350 (6317) :429-431

[13]

Buchanan R. L., 1977, Journal of Food Safety, V1, P19, DOI 10.1111/j.1745-4565.1977.tb00256.x

[14] ABILITY OF VARIOUS CARBON-SOURCES TO INDUCE AND SUPPORT AFLATOXIN SYNTHESIS BY ASPERGILLUS-PARASITICUS [J].

BUCHANAN, RL ;

STAHL, HG .

JOURNAL OF FOOD SAFETY, 1984, 6 (04) :271-279

[15]

Butchko RAE, 1999, GENETICS, V153, P715

[16] veA is required for toxin and sclerotial production in Aspergillus parasiticus [J].

Calvo, AM ;

Bok, J ;

Brooks, W ;

Keller, NP .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 70 (08) :4733-4739

[17] Relationship between secondary metabolism and fungal development [J].

Calvo, AM ;

Wilson, RA ;

Bok, JW ;

Keller, NP .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2002, 66 (03) :447-+

[18]

CALVO AM, 2008, FUNGAL GENET BIOL, V31, P31

[19] Gene duplication, modularity and adaptation in the evolution of the aflatoxin gene cluster [J].

Carbone, Ignazio ;

Ramirez-Prado, Jorge H. ;

Jakobek, Judy L. ;

Horn, Bruce W. .

BMC EVOLUTIONARY BIOLOGY, 2007, 7 (1)

[20] Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics [J].

Cary, J. W. ;

OBrian, G. R. ;

Nielsen, D. M. ;

Nierman, W. ;

Harris-Coward, P. ;

Bhatnagar, J. Yu D. ;

Cleveland, T. E. ;

Payne, G. A. ;

Calvo, A. M. .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2007, 76 (05) :1107-1118

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