Heck coupling with nonactivated alkenyl tosylates and phosphates: Examples of effective 1,2-migrations of the alkenyl palladium(II) intermediates

被引：166

作者：

Hansen, Anders L.

Ebran, Jean-Philippe

Ahlquist, Marten

Norrby, Per-Ola

Skrydstrup, Troels

机构：

[1] Kemitorvet Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark

[2] Univ Aarhus, inSPIN, Ctr Insoluble Prot Struct, Dept Chem, DK-8000 Aarhus, Denmark

[3] Univ Aarhus, Nanosci Ctr, DK-8000 Aarhus, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 20期

关键词：

1,2-migration; alkenes; Heck reaction; phosphates; tosylates;

D O I：

10.1002/anie.200600442

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) What the Heck! A catalytic system composed of a Pd complex with a basic, hindered alkyl phosphine ligand is capable of promoting Heck coupling of nonactivated vinyl tosylates and phosphates with electron-deficient olefins. An unexpected 1,2-migration of the alkenyl Pd II intermediates (see Scheme) leads to the isomerized Heck coupling product. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3349 / 3353

页数：5

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