Synthesis of a simplified sarcodictyin analogue which retains microtubule stabilising properties

被引：31

作者：

Telser, J

Beumer, R

Bell, AA

Ceccarelli, SM

Monti, D

Gennari, C

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] CNR, Ctr Studio Sostanze Organ Nat, I-20133 Milan, Italy

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 52期

关键词：

allylation; antitumour compounds; metathesis; stereocontrol;

D O I：

10.1016/S0040-4039(01)02045-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strategy featuring ring-closing metathesis as key reaction is applied to the synthesis of the sarcodictyin analogue 15. The precursor diene is accessed via a brief and efficient protocol. employing multiple stereoselective allylations. Simplified analogue 15 retains microtubule stabilising properties. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：9187 / 9190

页数：4

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