Symptom response after palliative radiotherapy for patients with brain metastases

被引:105
作者
Bezjak, A [1 ]
Adam, J
Barton, R
Panzarella, T
Laperriere, N
Wong, CS
Mason, W
Buckley, C
Levin, W
McLean, M
Wu, JSY
Sia, M
Kirkbride, P
机构
[1] Univ Toronto, Univ Hlth Network, Princess Margaret Hosp, Dept Radiat Oncol,Palliat Radiat Oncol Program, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Univ Hlth Network, Princess Margaret Hosp, Dept Med Oncol, Toronto, ON M5G 2M9, Canada
[3] Univ Toronto, Univ Hlth Network, Princess Margaret Hosp, Dept Biostat, Toronto, ON M5G 2M9, Canada
关键词
brain metastasis; radiotherapy; palliation; symptom response; quality of life;
D O I
10.1016/S0959-8049(01)00150-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Whole brain radiotherapy (RT) is frequently used to palliate symptoms in patients with brain metastases, but the palliative benefit to patients has not been well documented. We conducted a longitudinal observational prospective study of patients receiving standard RT (20 Gray (Gy)/5 fractions) for symptomatic brain metastases. End-points were observer rating of neurological symptoms, patient-rated symptoms, performance status, neurological functional status, cognitive function and quality of life (QOL). Median survival for the 75 patients was 86 days (95% confidence interval (CI): 65-101 days). At 1 month, 19% of patients showed an improvement or resolution of presenting symptoms, 23% were stable and 55% had progressed or died. Patient-rated symptoms were increased at 1 month in comparison to baseline data. only 4 patients had an improved performance status and 22 were stable. Many patients with brain metastases have a short life expectancy and may not benefit from even short duration radiation schedules. Further effort is needed to optimise patient selection and tailor treatment appropriately. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:487 / 496
页数:10
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