Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics

被引：80

作者：

Cruz, C

Camarena, B

King, N

Paez, F

Sidenberg, D

delaFuente, JR

Nicolini, H

机构：

[1] INST MEXICANO PSIQUIATRIA,PUIS,UNIDAD GENET MOL PSIQUIATR,DEPT GENET PSIQUIATR,DIV INVEST CLIN,MEXICO CITY 14370,DF,MEXICO

[2] CLARKE INST PSYCHIAT,DEPT NEUROGENET,TORONTO,ON M5T 1R8,CANADA

[3] SECRETARIA SALUD MEXICO,MEXICO CITY,DF,MEXICO

来源：

NEUROSCIENCE LETTERS | 1997年 / 231卷 / 01期

关键词：

dopamine D4 receptor gene (DRD4); DRD4 hypervariable segment; obsessive-compulsive disorder; tics; Tourette syndrome;

D O I：

10.1016/S0304-3940(97)00523-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The polymorphism characterized by a varying number of 48 bp repeats (VNTR) in the dopamine D4 receptor (DRD4) gene was examined in 61 obsessive-compulsive disorder (OCD) probands with and without ties. Most of the OCD patients with ties showed at least one copy of the 7-fold variant compared to those affected subjects without ties (91 vs. 48%, respectively, Yates corrected chi(2) = 5.54, P = 0.018), Similarly, a higher number of copies of this common variant were detected in the group of probands displaying ties compared to those OCD's without ties (Yates corrected chi(2) = 4.66, P = 0.03). Our study suggests that the seven-repeat allele of the DRD4 gene could be a factor in the phenotypic variance of ties among OCD individuals. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：1 / 4

页数：4