DAS181 treatment of severe parainfluenza type 3 pneumonia in a lung transplant recipient

被引：41

作者：

Drozd, D. R. ^{[1
]}

Limaye, A. P. ^{[1
]}

Moss, R. B. ^{[2
]}

Sanders, R. L. ^{[2
]}

Hansen, C. ^{[2
]}

Edelman, J. D. ^{[3
]}

Raghu, G. ^{[3
]}

Boeckh, M. ^{[1
,4
]}

Rakita, R. M. ^{[1
]}

机构：

[1] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA 98195 USA

[2] NexBio Inc, San Diego, CA USA

[3] Univ Washington, Dept Med, Div Pulm & Crit Care Med, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2013年 / 15卷 / 01期

关键词：

parainfluenza; DAS181; lung transplant; solid organ transplant; SIALIDASE FUSION PROTEIN; STEM-CELL TRANSPLANTATION; VIRUS-INFECTIONS; ADULT LUNG;

D O I：

10.1111/tid.12045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Parainfluenza virus (PIV) may cause life-threatening pneumonia in lung transplant patients and there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, to treat severe PIV type 3 pneumonia in a lung transplant patient. Treatment was well tolerated and associated with improvement in oxygenation and symptoms, along with rapid clearance of PIV. DAS181 should be systematically evaluated for treatment of PIV infection in transplant recipients.

引用

页码：E28 / E32

页数：5

共 15 条

[1] Respiratory Virus Pneumonia after Hematopoietic Cell Transplantation (HCT): Associations between Viral Load in Bronchoalveolar Lavage Samples, Viral RNA Detection in Serum Samples, and Clinical Outcomes of HCT [J].

Campbell, Angela P. ;

Chien, Jason W. ;

Kuypers, Jane ;

Englund, Janet A. ;

Wald, Anna ;

Guthrie, Katherine A. ;

Corey, Lawrence ;

Boeckh, Michael .

JOURNAL OF INFECTIOUS DISEASES, 2010, 201 (09) :1404-1413

[2] Treatment of Parainfluenza 3 Infection With DAS181 in a Patient After Allogeneic Stem Cell Transplantation [J].

Chen, Yi-Bin ;

Driscoll, Jessica P. ;

McAfee, Steven L. ;

Spitzer, Thomas R. ;

Rosenberg, Eric S. ;

Sanders, Rebecca ;

Moss, Ronald B. ;

Fang, Fang ;

Marty, Francisco M. .

CLINICAL INFECTIOUS DISEASES, 2011, 53 (07) :E77-E80

[3] Clinical potential of DAS181 for treatment of parainfluenza-3 infections in transplant recipients [J].

Guzman-Suarez, B. B. ;

Buckley, M. W. ;

Gilmore, E. T. ;

Vocca, E. ;

Moss, R. ;

Marty, F. M. ;

Sanders, R. ;

Baden, L. R. ;

Wurtman, D. ;

Issa, N. C. ;

Fang, F. ;

Koo, S. .

TRANSPLANT INFECTIOUS DISEASE, 2012, 14 (04) :427-433

[4] A Prospective Molecular Surveillance Study Evaluating the Clinical Impact of Community-Acquired Respiratory Viruses in Lung Transplant Recipients [J].

Kumar, Deepali ;

Husain, Shahid ;

Chen, Maggie Hong ;

Moussa, George ;

Himsworth, David ;

Manuel, Oriol ;

Studer, Sean ;

Pakstis, Diana ;

McCurry, Kenneth ;

Doucette, Karen ;

Pilewski, Joseph ;

Janeczko, Richard ;

Humar, Atul .

TRANSPLANTATION, 2010, 89 (08) :1028-1033

[5] Comparison of real-time PCR assays with fluorescent-antibody assays for diagnosis of respiratory virus infections in children [J].

Kuypers, Jane ;

Wright, Nancy ;

Ferrenberg, James ;

Huang, Meei-Li ;

Cent, Anne ;

Corey, Lawrence ;

Morrow, Rhoda .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (07) :2382-2388

[6] A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents [J].

Larson, Jeffrey L. ;

Kang, Seong-Kwi ;

Choi, Bo In ;

Hedlund, Maria ;

Aschenbrenner, Laura M. ;

Cecil, Beth ;

Machado, GloriaMay ;

Nieder, Matthew ;

Fang, Fang .

TOXICOLOGICAL SCIENCES, 2011, 122 (02) :567-578

[7] A multi-drug regimen for respiratory syncytial virus and parainfluenza virus infections in adult lung and heart-lung transplant recipients [J].

Liu, V. ;

Dhillon, G. S. ;

Weill, D. .

TRANSPLANT INFECTIOUS DISEASE, 2010, 12 (01) :38-44

[8] Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection [J].

Malakhov, MP ;

Aschenbrenner, LM ;

Smee, DF ;

Wandersee, MK ;

Sidwell, RW ;

Gubareva, LV ;

Mishin, VP ;

Hayden, FG ;

Kim, DH ;

Ing, A ;

Campbell, ER ;

Yu, M ;

Fang, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1470-1479

[9] A Recombinant Sialidase Fusion Protein Effectively Inhibits Human Parainfluenza Viral Infection In Vitro and In Vivo [J].

Moscona, Anne ;

Porotto, Matteo ;

Palmer, Samantha ;

Tai, Caroline ;

Aschenbrenner, Lori ;

Triana-Baltzer, Gallen ;

Li, Qi-Xiang ;

Wurtman, David ;

Niewiesk, Stefan ;

Fang, Fang .

JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (02) :234-241

[10] Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome [J].

Nichols, WG ;

Corey, L ;

Gooley, T ;

Davis, C ;

Boeckh, M .

BLOOD, 2001, 98 (03) :573-578

← 1 2 →