Release of amphotericin B from delivery systems and its action against fungal and mammalian cells

被引：49

作者：

Legrand, P ^{[1
]}

Cheron, M ^{[1
]}

Leroy, L ^{[1
]}

Bolard, J ^{[1
]}

机构：

[1] UNIV PARIS 06,UA CNRS 2056,LAB PHYSICO CHIM BIOMOL & CELLULAIRE,F-75252 PARIS 05,FRANCE

来源：

JOURNAL OF DRUG TARGETING | 1997年 / 4卷 / 05期

关键词：

amphotericin B; antifungal activity; Candida albicans; delivery systems; liposomes; release;

D O I：

10.3109/10611869708995847

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spectroscopic studies of four amphotericin B (AmB) lipid preparations-small negatively charged unilamellar vesicles ''AmBisome'', positively charged oligolamellar liposomes ''Ampholiposomes'', AmB Lipid Complex ''L-AmpB33''-and AmB association with gamma cyclodextrin demonstrated that the composition of drug delivery system directly influences AmB organization, The aggregation state and release in external medium of AmB was monitored by circular dichroism and UV-visible absorption. AmB short-term activity against Candida albicans (K+ leakage) was found to be correlated with the amount of free AmB released from lipid preparations, These data seem to indicate that lipid composition influences anti-Candida albicans activity, by modulation of AmB binding to lipids.

引用

页码：311 / 319

页数：9

共 25 条

[1]

Adler-Moore J.P., 1993, Journal of Liposome Research, V3, P429, DOI DOI 10.3109/08982109309150729

[2] PHYSICOCHEMICAL CELL-DAMAGE IN RELATION TO LETHAL AMPHOTERICIN-B ACTION [J].

BEGGS, WH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (02) :363-364

[3] ONE-SIDED ACTION OF AMPHOTERICIN-B ON CHOLESTEROL-CONTAINING MEMBRANES IS DETERMINED BY ITS SELF-ASSOCIATION IN THE MEDIUM [J].

BOLARD, J ;

LEGRAND, P ;

HEITZ, F ;

CYBULSKA, B .

BIOCHEMISTRY, 1991, 30 (23) :5707-5715

[4] AMPHOTERICIN-B INCORPORATED INTO EGG LECITHIN BILE-SALT MIXED MICELLES - MOLECULAR AND CELLULAR ASPECTS RELEVANT TO THERAPEUTIC EFFICACY IN EXPERIMENTAL MYCOSES [J].

BRAJTBURG, J ;

ELBERG, S ;

KOBAYASHI, GS ;

BOLARD, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (02) :300-306

[5] LIPOSOMAL AMPHOTERICIN-B (AMBISOME) IN THE TREATMENT OF FUNGAL-INFECTIONS IN NEUTROPENIC PATIENTS [J].

CHOPRA, R ;

BLAIR, S ;

STRANG, J ;

CERVI, P ;

PATTERSON, KG ;

GOLDSTONE, AH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 28 :93-104

[6] LIPOSOMAL AND LIPID FORMULATIONS OF AMPHOTERICIN-B - CLINICAL PHARMACOKINETICS [J].

JANKNEGT, R ;

DEMARIE, S ;

BAKKERWOUDENBERG, IAJM ;

CROMMELIN, DJA .

CLINICAL PHARMACOKINETICS, 1992, 23 (04) :279-291

[7] INFLUENCE OF PHOSPHOLIPID AMPHOTERICIN-B RATIO AND PHOSPHOLIPID TYPE ON INVITRO RENAL-CELL TOXICITIES AND FUNGICIDAL ACTIVITIES OF LIPID-ASSOCIATED AMPHOTERICIN-B FORMULATIONS [J].

JOLY, V ;

BOLARD, J ;

SAINTJULIEN, L ;

CARBON, C ;

YENI, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (02) :262-266

[8]

JULIANO RL, 1987, MOL PHARMACOL, V31, P1

[9] STUDY OF THE EFFECTS OF LIPOSOMAL AMPHOTERICIN-B ON CANDIDA-ALBICANS, CRYPTOCOCCUS-NEOFORMANS, AND ERYTHROCYTES BY USING SMALL UNILAMELLAR VESICLES PREPARED FROM SATURATED PHOSPHOLIPIDS [J].

JULLIEN, S ;

CONTREPOIS, A ;

SLIGH, JE ;

DOMART, Y ;

YENI, P ;

BRAJTBURG, J ;

MEDOFF, G ;

BOLARD, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (03) :345-349

[10] AFFINITY OF AMPHOTERICIN-B FOR PHOSPHATIDYLCHOLINE VESICLES AS A DETERMINANT OF THE INVITRO CELLULAR TOXICITY OF LIPOSOMAL PREPARATIONS [J].

JULLIEN, S ;

BRAJTBURG, J ;

BOLARD, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1021 (01) :39-45

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