Protein kinases of malaria parasites: an update

被引：90

作者：

Doerig, Christian ^{[1
]}

Billker, Oliver ^{[2
]}

Haystead, Timothy ^{[3
]}

Sharma, Pushkar ^{[4
]}

Tobin, Andrew B. ^{[5
]}

Waters, Norman C. ^{[6
]}

机构：

[1] Univ Glasgow, Biomed Res Ctr, Wellcome Ctr Mol Parasitol, INSERM,U609, Glasgow G12 8TA, Lanark, Scotland

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[3] Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA

[4] Natl Inst Immunol, Eukaryot Gene Express Lab, New Delhi 110067, India

[5] Univ Leicester, Dept Cell Physiol & Pharmacol, Leicester LE1 9HN, Leics, England

[6] Australian Army Malaria Inst, Qld Apo, Ap 96553, Australia

来源：

TRENDS IN PARASITOLOGY | 2008年 / 24卷 / 12期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.pt.2008.08.007

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Protein kinases (PKs) play crucial roles in the control of proliferation and differentiation in eukaryotic cells. Research on protein phosphorylation has expanded tremendously in the past few years, in part as a consequence of the realization that PKs represent attractive drug targets in a variety of diseases. Activity in Plasmodium PK research has followed this trend, and several reports on various aspects of this subject were delivered at the Molecular Approaches to Malaria 2008 meeting (MAM2008), a sharp increase from the previous meeting. Here, the authors of most of these communications join to propose an integrated update of the development of the rapidly expanding field of Plasmodium kinomics.

引用

页码：570 / 577

页数：8

共 69 条

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