MicroRNAs in Cerebral Ischemia-Induced Neurogenesis

被引：69

作者：

Liu, Xian Shuang ^{[1
]}

Chopp, Michael ^{[1
,2
]}

Zhang, Rui Lan ^{[1
]}

Zhang, Zheng Gang ^{[1
]}

机构：

[1] Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

[2] Oakland Univ, Dept Phys, Rochester, MI USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2013年 / 72卷 / 08期

基金：

美国国家卫生研究院;

关键词：

MiRNAs; Neural progenitor cells; Neurogenesis; Stroke; NEURAL STEM-CELLS; TRANSIENT GLOBAL-ISCHEMIA; NEURONAL PROGENITOR CELLS; ADULT SUBVENTRICULAR ZONE; SONIC HEDGEHOG PATHWAY; DENTATE GYRUS; IN-VITRO; EPIGENETIC REGULATION; NEUROBLAST MIGRATION; MAMMALIAN FOREBRAIN;

D O I：

10.1097/NEN.0b013e31829e4963

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral ischemia induces neurogenesis, including proliferation and differentiation of neural progenitor cells and migration of newly generated neuroblasts. MicroRNAs (miRNAs) are small noncoding RNAs that decrease gene expression through mRNA destabilization and/or translational repression. Emerging data indicate that miRNAs have a role in mediating processes of proliferation and differentiation of adult neural progenitor cells. This article reviews recent findings on miRNA profile changes in neural progenitor cells after cerebral infarction and the contributions of miRNAs to their ischemia-induced proliferation and differentiation. We highlight interactions between the miR-124 and the miR17-92 cluster and the Notch and Sonic hedgehog signaling pathways in mediating stroke-induced neurogenesis.

引用

页码：717 / 721

页数：5

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