Candidate-gene approaches for studying complex genetic traits: practical considerations

被引：710

作者：

Tabor, HK

Risch, NJ

Myers, RM ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[3] Kaiser Permanente, Div Res, Oakland, CA 94611 USA

来源：

NATURE REVIEWS GENETICS | 2002年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg796

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of nonreplication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.

引用

页码：391 / A396

页数：7

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