The genetic basis of premature ovarian failure

被引：88

作者：

Woad, KJ ^{[1
]}

Watkins, WJ ^{[1
]}

Prendergast, D ^{[1
]}

Shelling, AN ^{[1
]}

机构：

[1] Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, Auckland 1, New Zealand

来源：

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | 2006年 / 46卷 / 03期

关键词：

candidate gene; FOXL2; genetic disorder; inhibin; premature ovarian failure;

D O I：

10.1111/j.1479-828X.2006.00585.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Premature ovarian failure (POF) is a common condition, affecting approximately 1:100 women. It is characterised by amenorrhea, hypoestrogenism, and elevated gonadotrophin levels in women under the age of 40. It is often an unexpected and distressing diagnosis, which coincides with infertility and menopausal symptoms. There is a well recognised genetic basis to the development of POF. Our laboratory has identified several candidate genes associated with POF.

引用

页码：242 / 244

页数：3

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