A likely intermediate during the CO2-induced activation of 2-alkylindoles toward electrophilic substitution: Structure of a unique tetramer formed by joining two boat-shaped (LiOCO)(2) rings

被引：15

作者：

Davies, RP ^{[1
]}

Raithby, PR ^{[1
]}

Snaith, R ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT CHEM,CAMBRIDGE CB2 1EW,ENGLAND

来源：

ORGANOMETALLICS | 1996年 / 15卷 / 21期

关键词：

D O I：

10.1021/om960739a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction, of 2,3-dimethylindole in thf with (n)BuLi and CO2 gives a lithium carbamate complex (2 . thf)(n), which has a unique tetrameric solid-state structure (n = 4) containing two boat-shaped (-LiO-COLiOCO-) rings joined by four inter-ring Li-O connections. The two-coordinate O atoms of these rings are near to the 2-Me groups of the indolyl residues, suggesting an explanation for second lithiation (and subsequent electrophilic substitution) of 2-alkylindoles and related heterocyclics occurring specifically at the 2-alkyl position.

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页码：4355 / 4356

页数：2

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