Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk

被引:100
作者
Taylor, BA
Tofler, GH
Carey, HMR
Morel-Kopp, MC
Philcox, S
Carter, TR
Elliott, MJ
Kull, AD
Ward, C
Schenck, K
机构
[1] Sydney Dent Hosp, Surry Hills, NSW 2010, Australia
[2] Univ Oslo, Dept Oral Biol, N-0316 Oslo, Norway
关键词
periodontal disease; cardiovascular disease;
D O I
10.1177/154405910608500113
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied 67 adults with advanced periodontitis requiring full-mouth tooth extraction. Blood samples were obtained: (1) at initial presentation, immediately prior to treatment of presenting symptoms; (2) one to two weeks later, before all teeth were removed; and (3) 12 weeks after full-mouth tooth extraction. After full-mouth tooth extraction, there was a significant decrease in C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen, and white cell and platelet counts. This study shows that elimination of advanced periodontitis by full-mouth tooth extraction reduces systemic inflammatory and thrombotic markers of cardiovascular risk. Analysis of the data supports the hypothesis that treatment of periodontal disease may lower cardiovascular risk, and provides a rationale for further randomized studies.
引用
收藏
页码:74 / 78
页数:5
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