The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007

被引:68
作者
Huang, Yuan-Pin [1 ]
Lin, Tsuey-Li [1 ]
Kuo, Chuan-Yi [1 ]
Lin, Miao-Wen [1 ]
Yao, Ching-Yuan [1 ]
Liao, Hui-Wen [1 ]
Hsu, Li-Ching [1 ]
Yang, Chen-Fu [1 ]
Yang, Jyh-Yuan [1 ]
Chen, Pei-Jer [2 ]
Wu, Ho-Sheng [1 ,3 ]
机构
[1] Ctr Dis Control, Res & Diagnost Ctr, Dept Hlth, Taipei 11561, Taiwan
[2] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan
[3] Taipei Med Univ, Sch Med Lab Sci & Biotechnol, Taipei, Taiwan
关键词
Enterovirus; 71; Phylogenetic analysis; Subgenogroup;
D O I
10.1016/j.virusres.2008.07.015
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Enteroviruses (EVs) are among the most common pathogens in humans. EV71 infections have caused devastating enterovirus-associated outcomes in children globally. In this study, eleven EV71 isolates in Taiwan during 2006-2007 were selected for N-terminal VP1 gene analysis. A fragment of 403 bp on VP1 gene was sequenced and a phylogenetic analysis was performed. In addition, the full-length genome sequencing was carried out on two selected isolates. The results showed that subgenogroups of B5 and C5 had circulated and become predominant in Taiwan over the specified 2 years. Moreover, glutamic acid and threonine are found conservative at positions 43 and 58 on VP1 for genogroup B: however they are replaced by lysine and alanine, respectively, for genogroup C. To our knowledge, this is the first report describing the circulation of these two EV71 subgenogroups in Taiwan. (c) 2008 Published by Elsevier B.V.
引用
收藏
页码:206 / 212
页数:7
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