Disruption of Nectin-Like 1 Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS

被引：47

作者：

Park, Jinsil ^{[3
]}

Liu, Ben ^{[1
,2
]}

Chen, Tao ^{[1
,2
]}

Li, Hong ^{[3
]}

Hu, Xuemei ^{[3
]}

Gao, Jing ^{[1
,2
]}

Zhu, Ying ^{[3
]}

Zhu, Qiang ^{[3
]}

Qiang, Boqin ^{[1
,2
]}

Yuan, Jiangang ^{[1
,2
]}

Peng, Xiaozhong ^{[1
,2
]}

Qiu, Mengsheng ^{[3
,4
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

[3] Univ Louisville, Sch Med, Dept Anat Sci & Neurobiol, Louisville, KY 40292 USA

[4] Tianjin Med Univ, Inst Urol Surg, Tianjin 300211, Peoples R China

来源：

JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 48期

基金：

美国国家卫生研究院;

关键词：

cell adhesion molecule; gene targeting; myelination; spinal cord; optic nerve; knock-out;

D O I：

10.1523/JNEUROSCI.2665-08.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the axon-glial interaction and myelin sheath formation in the PNS. To investigate the in vivo role of Necl-1 in axonal myelination of the developing nervous system, we generated the Necl-1 mutant mice by replacing axons 2-5 with the LacZ reporter gene. Expression studies revealed that Necl-1 is exclusively expressed by neurons in the CNS. Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.

引用

页码：12815 / 12819

页数：5

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