Hsp90 as a target for drug development

被引：76

作者：

Chaudhury, Subhabrata

Welch, Timothy R.

Blagg, Brian S. J.

机构：

来源：

CHEMMEDCHEM | 2006年 / 1卷 / 12期

关键词：

D O I：

10.1002/cmdc.200600112

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Heat shock protein 90 (Hsp90) has emerged as a promising target for the treatment of cancer, Alzheimer's and Parkinson's diseases, motor impairments, multiple sclerosis, and other disorders. Progress toward the development of both N and C-terminal inhibitors is described.

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页码：1331 / +

页数：11

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