Highly cis-selective synthesis of iodo-aziridines using diiodomethyllithium and in situ generated N-Boc-imines

被引：24

作者：

Bull, James A. ^{[1
]}

Boultwood, Tom ^{[1
]}

Taylor, Thomas A. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 100期

基金：

英国工程与自然科学研究理事会;

关键词：

TERMINAL AZIRIDINES; ASYMMETRIC AZIRIDINATION; SUBSTITUTED AZIRIDINES; ADDITION-REACTIONS; AMINO-ALCOHOLS; LITHIATION; CYCLIZATION; REACTIVITY; NITROGEN; EPOXIDES;

D O I：

10.1039/c2cc37029h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first preparation of iodoaziridines is described. The addition of diiodomethyllithium to N-Boc-imines affords these novel aziridines in high yields. The reaction proceeds in one-pot via a highly diastereoselective cyclisation of an amino gem-diiodide intermediate.

引用

页码：12246 / 12248

页数：3

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